GATA-1 (D24E4) Rabbit Monoclonal Antibody #4589
- WB
- IP
- F
Product Specifications
| REACTIVITY | H |
| SENSITIVITY | Endogenous |
| MW (kDa) | 43 |
| Source/Isotype | Rabbit IgG |
Application Key:
- WB-Western Blotting
- IP-Immunoprecipitation
- F-Flow Cytometry
Species Cross-Reactivity Key:
- H-Human
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
| Immunoprecipitation | 1:50 |
| Flow Cytometry (Fixed/Permeabilized) | 1:50 |
Storage
For a carrier free (BSA and azide free) version of this product see product #27425.
Protocol
Specificity / Sensitivity
Species Reactivity:
Source / Purification
Background
GATA-1 is the founding member of the GATA family and is required for erythroid and megakaryocytic cell development (4,5). Mutations in the corresponding GATA-1 gene are linked to many human diseases, including acute megakaryoblastic leukemia in Down Syndrome children (DS-AMKL), X-linked thrombocytopenia, and gray platelet syndrome (6-9).
- Ko, L.J. and Engel, J.D. (1993) Mol Cell Biol 13, 4011-22.
- Merika, M. and Orkin, S.H. (1993) Mol Cell Biol 13, 3999-4010.
- Lowry, J.A. and Atchley, W.R. (2000) J Mol Evol 50, 103-15.
- Pevny, L. et al. (1991) Nature 349, 257-60.
- Fujiwara, Y. et al. (1996) Proc Natl Acad Sci USA 93, 12355-8.
- Wechsler, J. et al. (2002) Nat Genet 32, 148-52.
- Cantor, A.B. (2005) Int J Hematol 81, 378-84.
- Mehaffey, M.G. et al. (2001) Blood 98, 2681-8.
- Tubman, V.N. et al. (2007) Blood 109, 3297-9.
Alternate Names
ERYF1; Erythroid transcription factor; erythroid transcription factor 1; GATA binding protein 1; GATA binding protein 1 (globin transcription factor 1); GATA-1; GATA-binding factor 1; GATA1; GF-1; GF1; globin transcription factor 1; NF-E1; NF-E1 DNA-binding protein; NFE1; nuclear factor, erythroid 1; transcription factor GATA1; XLANP; XLTDA; XLTT
Limited Uses
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