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Glut2 (F6X2X) Rabbit Monoclonal Antibody #90520

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  • WB

    Product Specifications

    REACTIVITY H
    SENSITIVITY Endogenous
    MW (kDa) 50-80
    Source/Isotype Rabbit IgG
    Application Key:
    • WB-Western Blotting 
    Species Cross-Reactivity Key:
    • H-Human 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    Glut2 (F6X2X) Rabbit Monoclonal Antibody recognizes endogenous levels of total Glut2 protein. This antibody does not cross-react with Glut1, Glut3, Glut4, or Glut5 protein. This antibody detects a 35 kDa and a 160 kDa protein of unknown identity in some cell lines.

    Species Reactivity:

    Human

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human Glut2 protein.

    Background

    Glucose transporter 2 (Glut2), also known as SLC2A2, is a facilitated hexose transporter. It transports glucose, fructose, and galactose (1-3). Glut2 is expressed in various tissues, such as liver, small intestine, kidney, pancreatic β cells, and central nervous system (1,4). In addition, Glut2 is a marker of mature pancreatic β cells and is required for glucose-stimulated insulin secretion there (1,5). Furthermore, a mutation on human Glut2 protein expressed in Xenopus oocytes where Val197 is changed to isoleucine was shown to abolish its transport activity (6).

    Alternate Names

    Glucose transporter type 2, liver; GLUT-2; GLUT2; GTR2; SLC2A2; solute carrier family 2 (facilitated glucose transporter), member 2; solute carrier family 2 member 2; Solute carrier family 2, facilitated glucose transporter member 2

    For Research Use Only. Not for Use in Diagnostic Procedures.
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