Interested in promotions? | Click here >>
94905
PhosphoPlus® Glycogen Synthase (Ser641) Antibody Duet
Primary Antibodies
Antibody Duet

PhosphoPlus® Glycogen Synthase (Ser641) Antibody Duet #94905

Reviews ()
Citations (0)
PhosphoPlus® Glycogen Synthase (Ser641) Antibody Duet: Image 1

Immunohistochemical analysis of paraffin-embedded human ductal carcinoma of the breast using Phospho-Glycogen Synthase (Ser641) (D4H1B) XP® Rabbit mAb in the presence of control peptide (left) or antigen-specific peptide (right).

PhosphoPlus® Glycogen Synthase (Ser641) Antibody Duet: Image 2

Immunohistochemical analysis of paraffin-embedded human lung carcinoma, using Glycogen Synthase (15B1) Rabbit mAb.

PhosphoPlus® Glycogen Synthase (Ser641) Antibody Duet: Image 3

Immunohistochemical analysis of paraffin-embedded human lung carcinoma using Phospho-Glycogen Synthase (Ser641) (D4H1B) XP® Rabbit mAb.

PhosphoPlus® Glycogen Synthase (Ser641) Antibody Duet: Image 4

Western blot analysis of extracts from various cell lines, using Glycogen Synthase (15B1) Rabbit mAb.

PhosphoPlus® Glycogen Synthase (Ser641) Antibody Duet: Image 5

Immunohistochemical analysis of paraffin-embedded human endometrioid adenocarcinoma, untreated (left) or λ phosphatase treated (right), using Phospho-Glycogen Synthase (Ser641) (D4H1B) XP® Rabbit mAb.

PhosphoPlus® Glycogen Synthase (Ser641) Antibody Duet: Image 6

Immunohistochemical analysis of paraffin-embedded human squamous cell carcinoma of the lung using Phospho-Glycogen Synthase (Ser641) (D4H1B) XP® Rabbit mAb.

PhosphoPlus® Glycogen Synthase (Ser641) Antibody Duet: Image 7

Western blot analysis of extracts from NIH/3T3 cells, untreated (-) or treated (+) with λ phosphatase and calf intestinal alkaline phosphatase (CIP), using Phospho-Glycogen Synthase (Ser641) (D4H1B) XP® Rabbit mAb (upper) or Glycogen Synthase (15B1) Rabbit mAb #3886 (lower).

To Purchase # 94905S
Product # Size Price
94905S
1 Kit $ 537

Product Description

PhosphoPlus® Duets from Cell Signaling Technology (CST) provide a means to assess protein activation status. Each Duet contains an activation-state and total protein antibody to your target of interest. These antibodies have been selected from CST's product offering based upon superior performance in specified applications.

Background

Glycogen is a polysaccharide of glucose and serves as an energy storage in mammalian muscle and liver (1). Glycogen synthase catalyzes the rate-limiting step of glycogen biosynthesis and has two major isoforms in mammals -- muscle isoform (GYS1) and liver isoform (GYS2) respectively (1). Glycogen synthase kinase-3α (GSK-3α) and glycogen synthase kinase-3β (GSK-3β) phosphorylate glycogen synthase at multiple sites in its C-terminus (Ser641, Ser645, Ser649 and Ser653) inhibiting its activity (2, 3). Hypoxia alters glycogen metabolism including temporal changes of GYS1 expression and phosphorylation in cancer cells, suggesting the role of metabolic reprogramming of glycogen metabolism in cancer growth (1).

  1. Favaro, E. et al. (2012) Cell Metab 16, 751-64.
  2. Mora, A. et al. (2005) FEBS Lett 579, 3632-8.
  3. Jensen, J. et al. (2012) Am J Physiol Endocrinol Metab 303, E82-9.

Pathways & Proteins

Explore pathways + proteins related to this product.

Limited Uses

Except as otherwise expressly agreed in a writing signed by a legally authorized representative of CST, the following terms apply to Products provided by CST, its affiliates or its distributors. Any Customer's terms and conditions that are in addition to, or different from, those contained herein, unless separately accepted in writing by a legally authorized representative of CST, are rejected and are of no force or effect.

Products are labeled with For Research Use Only or a similar labeling statement and have not been approved, cleared, or licensed by the FDA or other regulatory foreign or domestic entity, for any purpose. Customer shall not use any Product for any diagnostic or therapeutic purpose, or otherwise in any manner that conflicts with its labeling statement. Products sold or licensed by CST are provided for Customer as the end-user and solely for research and development uses. Any use of Product for diagnostic, prophylactic or therapeutic purposes, or any purchase of Product for resale (alone or as a component) or other commercial purpose, requires a separate license from CST. Customer shall (a) not sell, license, loan, donate or otherwise transfer or make available any Product to any third party, whether alone or in combination with other materials, or use the Products to manufacture any commercial products, (b) not copy, modify, reverse engineer, decompile, disassemble or otherwise attempt to discover the underlying structure or technology of the Products, or use the Products for the purpose of developing any products or services that would compete with CST's products or services, (c) not alter or remove from the Products any trademarks, trade names, logos, patent or copyright notices or markings, (d) use the Products solely in accordance with CST's Product Terms of Sale and any applicable documentation, and (e) comply with any license, terms of service or similar agreement with respect to any third party products or services used by Customer in connection with the Products.

For Research Use Only. Not For Use In Diagnostic Procedures.
Cell Signaling Technology is a trademark of Cell Signaling Technology, Inc.
CST is a trademark of Cell Signaling Technology, Inc.
SignalStain is a trademark of Cell Signaling Technology, Inc.
XP is a registered trademark of Cell Signaling Technology, Inc.
Tween is a registered trademark of ICI Americas, Inc.