Render Target: STATIC
Render Timestamp:
5/22/2026, 7:14:37 AM EDT
5/22/2026, 11:14:37 AM UTC
Commit: 7ed46ecc04b401f23a28df741b5078df405d23e4
XML generation date: 2025-11-13 17:58:53.429
Product last modified at: 2026-03-20T08:02:08.026Z
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PDP - Template Name: Polyclonal Antibody
PDP - Template ID: *******59c6464

Homer1 Antibody #8231

Filter:
  • WB

    Product Specifications

    REACTIVITY H M R
    SENSITIVITY Endogenous
    MW (kDa) 46
    SOURCE Rabbit
    Application Key:
    • WB-Western Blotting 
    Species Cross-Reactivity Key:
    • H-Human 
    • M-Mouse 
    • R-Rat 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    Homer1 Antibody detects endogenous levels of total Homer1 protein. This antibody may also detect isoform Homer1c.

    Species Reactivity:

    Human, Mouse, Rat

    Source / Purification

    Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Glu130 of human Homer1 protein. Antibodies are purified by protein A and peptide affinity chromatography.

    Background

    Homer1, Homer2 and Homer3 are scaffolding proteins, composed of an EVH protein–binding domain, a coiled-coil domain and a leucine zipper domain. The EVH domain is a protein-protein binding module that binds to the proline-rich motifs PPXXF, PPXF, and LPSSP of G protein–coupled receptors (GPCRs), inositol 1,4,5-triphosphate (IP3) receptors (IP3Rs), ryanodine receptors, and TRP channels (1-2). The coiled-coil and the leucine zipper domains cause multimerization of Homers and assemble signaling proteins complexes. The Homer1 gene encodes a short isoform (Homer1a, aa 1-186) and two long isoforms (Homer1b, aa 1-354; Homer1c, aa 1-366). Homer1a lacks the coiled-coil domain and leucine zipper, antagonizing multimerization of Homers and thus disassembling signaling proteins complexes (3).

    Alternate Names

    HOME1; HOMER; homer homolog 1; homer homolog 1 (Drosophila); Homer protein homolog 1; homer scaffold protein 1; homer scaffolding protein 1; Homer-1; homer, neuronal immediate early gene, 1; HOMER1; HOMER1A; HOMER1B; HOMER1C; SYN47; Ves-1

    For Research Use Only. Not for Use in Diagnostic Procedures.
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