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  3. HSP10 (F8X5Y) Rabbit Monoclonal Antibody
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Recombinant: Superior lot-to-lot consistency, continuous supply, and animal-free manufacturing.

HSP10 (F8X5Y) Rabbit Monoclonal Antibody #53668

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  • WB

    Product Specifications

    REACTIVITY H M R
    SENSITIVITY Endogenous
    MW (kDa) 10
    Source/Isotype Rabbit IgG
    Application Key:
    • WB-Western Blotting 
    Species Cross-Reactivity Key:
    • H-Human 
    • M-Mouse 
    • R-Rat 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000
    Simple Western™ 1:10 - 1:50

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    HSP10 (F8X5Y) Rabbit Monoclonal Antibody recognizes endogenous levels of total HSP10 protein.

    Species Reactivity:

    Human, Mouse, Rat

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human HSP10 protein.

    Background

    Impaired mitochondrial integrity and function lead to the activation of a transcriptional response known as the mitochondrial unfolded protein response (UPRmt) (1). Mitochondrial 10 kDa heat shock protein (HSP10), also known as heat shock protein family E member 1 (HSPE1), is a mitochondria-specific protein chaperone and a component in the UPRmt pathway. Studies show that Akt3 depletion in primary endothelial cells causes mitochondrial stress and leads to upregulated expression of HSP10 along with HSP60, another mitochondria-specific protein chaperone. This finding suggests a critical role of Akt3 in maintaining mitochondrial homeostasis (2). In addition, HSP10 and HSP60 chaperones were shown to be the most abundant mitochondrial proteins (3).

    Alternate Names

    10 kDa chaperonin; 10 kDa heat shock protein, mitochondrial; CH10; Chaperonin 10; CPN10; Early-pregnancy factor; EPF; epididymis secretory sperm binding protein; GROES; heat shock 10kD protein 1 (chaperonin 10); heat shock 10kDa protein 1; heat shock 10kDa protein 1 (chaperonin 10); heat shock protein family E (Hsp10) member 1; Hsp10; HSPE1

    Database Links

    UniProt ID: P61604


    Entrez-Gene Id: 3336


    Limited Uses

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    For Research Use Only. Not for Use in Diagnostic Procedures.
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