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To Purchase # 9770T

9770T 1 Kit (5 x 20 µl) $359.00.0


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Product Includes Quantity Applications Reactivity MW(kDa) Isotype
c-IAP1 (D5G9) Rabbit mAb 7065 20 µl
Western Blotting Immunoprecipitation
H 62 Rabbit IgG
c-IAP2 (58C7) Rabbit mAb 3130 20 µl
Western Blotting Immunoprecipitation
H 70 Rabbit IgG
Survivin (71G4B7) Rabbit mAb 2808 20 µl
Western Blotting Immunoprecipitation Immunohistochemistry Immunofluorescence Flow Cytometry
H M R 16 Rabbit IgG
XIAP (3B6) Rabbit mAb 2045 20 µl
Western Blotting
H Mk 53 Rabbit IgG
Livin (D61D1) XP® Rabbit mAb 5471 20 µl
Western Blotting Immunoprecipitation Immunofluorescence
H 34, 36 Rabbit IgG
Anti-rabbit IgG, HRP-linked Antibody 7074 100 µl
Western Blotting

Product Description

The IAP Family Antibody Sampler Kit provides an economical means to investigate the expression of various IAP family members within the cell. The kit contains enough primary and secondary antibodies to perform two Western blot experiments.

Specificity / Sensitivity

Each antibody in the IAP Family Antibody Sampler Kit detects endogenous levels of its respective target.

Source / Purification

Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Leu28 of human c-IAP1 protein. The antibody is purified by protein A and affinity chromatography. Monoclonal antibodies are produced by immunizing animals with synthetic peptides corresponding to residues surrounding Val117 of human c-IAP2, Cys60 of human Survivin, Ser245 of human XIAP, and Ala195 of human Livin.

The inhibitor of apoptosis protein (IAP) family consists of an evolutionarily conserved group of apoptosis inhibitors containing a conserved 70 amino acid BIR (baculovirus inhibitor repeat) domain (1,2). Human members of this family include c-IAP1, c-IAP2, XIAP, survivin, livin, and NAIP. Overexpression of IAP family members, particularly survivin and livin, in cancer cell lines and primary tumors suggests an important role for these proteins in cancer progression (3-5). In general, the IAP proteins function through direct interactions to inhibit the activity of several caspases, including caspase-3, caspase-7, and caspase-9 (5,6). In addition, binding of IAP family members to the mitochondrial protein Smac blocks their interaction with caspase-9, thereby allowing the processing and activation of the caspase (2).

1.  Deveraux, Q.L. and Reed, J.C. (1999) Genes Dev 13, 239-52.

2.  Deveraux, Q.L. et al. (1998) EMBO J 17, 2215-23.

3.  Altieri, D.C. et al. (1999) Lab Invest 79, 1327-33.

4.  Tamm, I. et al. (2000) Clin Cancer Res 6, 1796-803.

5.  Kasof, G.M. and Gomes, B.C. (2001) J Biol Chem 276, 3238-46.

6.  Deveraux, Q.L. et al. (1997) Nature 388, 300-4.

Entrez-Gene Id 329 , 330 , 79444 , 332 , 331
Swiss-Prot Acc. Q13490 , Q13489 , Q96CA5 , O15392 , P98170

For Research Use Only. Not For Use In Diagnostic Procedures.
Cell Signaling Technology is a trademark of Cell Signaling Technology, Inc.
U.S. Patent No. 7,429,487, foreign equivalents, and child patents deriving therefrom.

IAP Family Antibody Sampler Kit