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Render Timestamp: 2024-12-09T11:57:53.096Z
Commit: 224419269841c11382c4555dbee545259bf6c379
XML generation date: 2024-10-08 04:01:11.059
Product last modified at: 2024-10-05T08:00:12.561Z
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PDP - Template Name: Antibody Sampler Kit
PDP - Template ID: *******4a3ef3a

Immunosuppressive Tumor Microenvironment IHC Antibody Sampler Kit #67524

    Product Information

    Product Description

    The Immunosuppressive Tumor Microenvironment IHC Antibody Sampler Kit provides an economical means of detecting CD8+ T cells and various markers of immunosuppressive cell types and mechanisms in formalin-fixed paraffin-embedded human tumor tissue samples.

    Background

    The immune system has the capability to detect and eliminate tumor cells, most notably through cytotoxic CD8+ T cell recognition of tumor antigens presented on the surface of tumor cells by MHC class I molecules. However, anti-tumor immune cells can be subject to various immunosuppressive mechanisms in the tumor microenvironment (TME). One of these mechanisms is the upregulation of PD-L1 by tumor cells and myeloid cells, which suppresses T cell function through interaction with PD-1 (1,2). In addition, the tumor can recruit immunosuppressive cells, such as FoxP3+ regulatory T cells, and can promote polarization of cells to a pro-tumor and immunosuppressive phenotype, such as CD68+CD206+M2-like macrophages (3,4). The infiltration and function of cytotoxic CD8+ T cells can also be suppressed by stromal cells such as LRRC15+ immunosuppressive cancer-associated fibroblasts (CAFs) (5).
    For Research Use Only. Not For Use In Diagnostic Procedures.
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