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IMP1 (D33A2) Rabbit mAb #8482

Filter:
  • WB
  • IP
  • eCLIP

    Supporting Data

    REACTIVITY H M R
    SENSITIVITY Endogenous
    MW (kDa) 64
    Source/Isotype Rabbit IgG
    Application Key:
    • WB-Western Blotting 
    • IP-Immunoprecipitation 
    • eCLIP-eCLIP 
    Species Cross-Reactivity Key:
    • H-Human 
    • M-Mouse 
    • R-Rat 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000
    Immunoprecipitation 1:50
    eCLIP 1:200
    For more information about the RBP-eCLIP service please visit Eclipsebio.

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    IMP1 (D33A2) Rabbit mAb recognizes endogenous levels of total IMP1 protein.

    Species Reactivity:

    Human, Mouse, Rat

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the amino terminus of human IMP1 protein.

    Background

    Insulin-like growth factor-II mRNA-binding proteins (IMPs) belong to a family of zipcode-binding proteins (1,2). Three members of this family, IMP1, IMP2, and IMP3, have been identified (1,2). They contain two RNA recognition motifs, four K homology domains, and were found to function in mRNA localization, turnover, and translation control (1,2). Research studies have implicated these proteins in a variety of physiological and pathological processes, such as growth and development (3), testicular neoplasia (4), and melanocytic neoplasia (5).

    Alternate Names

    Coding region determinant-binding protein; CRD-BP; CRDBP; IF2B1; IGF II mRNA binding protein 1; IGF-II mRNA-binding protein 1; IGF2 mRNA-binding protein 1; IGF2BP1; IMP-1; IMP1; insulin-like growth factor 2 mRNA binding protein 1; Insulin-like growth factor 2 mRNA-binding protein 1; RNA transport; VICKZ family member 1; VICKZ1; ZBP-1; ZBP1; Zip code-binding protein 1; Zipcode-binding protein 1

    For Research Use Only. Not for Use in Diagnostic Procedures.
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