Integrin αV Antibody #4711
- WB
- IP
Supporting Data
| REACTIVITY | H R |
| SENSITIVITY | Endogenous |
| MW (kDa) | 135, 140 |
| SOURCE | Rabbit |
Application Key:
- WB-Western Blotting
- IP-Immunoprecipitation
Species Cross-Reactivity Key:
- H-Human
- R-Rat
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
| Immunoprecipitation | 1:50 |
Storage
Protocol
Specificity / Sensitivity
Species Reactivity:
Source / Purification
Background
Several αV subfamily members, including αVβ3, αVβ5, αVβ1, are highly expressed in active endothelial cells and cancer cells (3-6) where they play a critical role in angiogenesis and tumor metastasis (7-9). Therefore, interest has focused on αV integrin as a key therapeutic target in the treatment of cancer (10-12).
- Liu, S. et al. (2000) J Cell Sci 113 ( Pt 20), 3563-71.
- Hood, J.D. and Cheresh, D.A. (2002) Nat Rev Cancer 2, 91-100.
- Koistinen, P. et al. (2004) Int J Cancer 112, 61-70.
- Davidson, B. et al. (2003) Gynecol Oncol 90, 248-57.
- Schwartz, E.A. et al. (1999) Circ Res 84, 315-22.
- Suzuma, K. et al. (1998) Invest Ophthalmol Vis Sci 39, 1028-35.
- Eliceiri, B.P. and Cheresh, D.A. (1999) J Clin Invest 103, 1227-30.
- Friedlander, M. et al. (1995) Science 270, 1500-2.
- Perruzzi, C.A. et al. (2003) J Invest Dermatol 120, 1100-9.
- Strieth, S. et al. (2006) Int J Cancer 119, 423-31.
- Kumar, C.C. (2003) Curr Drug Targets 4, 123-31.
- Tucker, G.C. (2006) Curr Oncol Rep 8, 96-103.
Limited Uses
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