INTS6 (F1S8S) Rabbit Monoclonal Antibody #17877
- WB
- IP
Product Specifications
| REACTIVITY | H M R |
| SENSITIVITY | Endogenous |
| MW (kDa) | 120 |
| Source/Isotype | Rabbit IgG |
Application Key:
- WB-Western Blotting
- IP-Immunoprecipitation
Species Cross-Reactivity Key:
- H-Human
- M-Mouse
- R-Rat
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
| Simple Western™ | 1:50 - 1:250 |
| Immunoprecipitation | 1:50 |
Storage
Protocol
Specificity / Sensitivity
Species Reactivity:
Source / Purification
Background
INTS6 (integrator complex subunit 6), also known as DICE1 (deleted in cancer 1), was first identified in non-small cell lung cancer cells and within the 13q14 chromosomal region (4). Given the susceptibility of this region to allelic deletions in many solid tumors, INTS6 has been extensively examined as a tumor suppressor gene in humans (4-6). This protein was also identified as one of the integrator complex subunits (7). Its primary role is to facilitate protein phosphatase 2A (PP2A) assembly into the integrator-PP2A complex, ultimately contributing to target gene repression (8). Downregulation of INTS6 expression is associated with a poorer prognosis in hepatocellular carcinoma patients (9), while INTS6 levels were found to be significantly increased in colorectal carcinoma tissues and associated with poor prognosis (10).
- Kirstein, N. et al. (2021) Curr Opin Cell Biol 70, 37-43.
- Nojima, T. and Proudfoot, N.J. (2022) Nat Rev Mol Cell Biol 23, 389-406.
- Wieland, I. et al. (1999) Oncogene 18, 4530-7.
- Li, W.J. et al. (2003) Oncogene 22, 314-8.
- Filleur, S. et al. (2009) Cancer Cell Int 9, 28.
- Baillat, D. et al. (2005) Cell 123, 265-76.
- Zheng, H. et al. (2020) Science 370, eabb5872. doi: 10.1126/science.abb5872.
- Lui, K.Y. et al. (2017) BMC Cancer 17, 644.
- Ding, X. et al. (2021) Exp Cell Res 407, 112826.
Alternate Names
AL354820.3; DBI-1; DBI1; DDX26; DDX26A; DEAD box protein; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 26; DICE1; DKFZp434B105; HDB; Int6; Integrator complex subunit 6; INTS6; Notchl2; Protein DDX26; Protein deleted in cancer 1; RNA helicase HDB
Limited Uses
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