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14961
IRX1 (D5S8Y) Rabbit mAb

IRX1 (D5S8Y) Rabbit mAb #14961

This product is discontinued

Storage:

Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

IRX1 (D5S8Y) Rabbit mAb recognizes endogenous levels of total IRX1 protein.

Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro466 of human IRX1 protein.

The Iroquois-class homeodomain proteins (IRX1-6) comprise a family of transcription factors, initially identified in a mutagenesis experiment in Drosophila designed to identify genes involved in embryonic patterning (1, 2). Members of the Iroquois-class protein family contain a three amino acid loop extension (TALE) homeodomain and an IRO sequence motif of unknown function that is unique to this protein family, but which bears similarity to Notch receptor domains involved in protein-protein interactions (3, 4). Research studies in various animal models suggest important roles for IRX proteins in early development, including neural patterning, heart field specification, kidney development and lung development (5-8). Moreover, studies in mice have shown an essential role for IRX proteins in eye development, where they are required for the specification of ommatidia and photoreceptor cells (9).

The human IRX1 gene has been identified as a candidate tumor suppressor (10) that is hypermethylated in a number of cancer subtypes (11). Research studies in head and neck squamous cell carcinoma cell lines specifically suggest that IRX1 interacts with components of the TGFβ signaling pathway to regulate cell proliferation and differentiation (12).

  1. Dambly-Chaudière, C. and Leyns, L. (1992) Int J Dev Biol 36, 85-91.
  2. Leyns, L. et al. (1996) Mech Dev 59, 63-72.
  3. Cavodeassi, F. et al. (2001) Development 128, 2847-55.
  4. Lai, E.C. et al. (1998) Development 125, 4077-88.
  5. Bosse, A. et al. (1997) Mech Dev 69, 169-81.
  6. Christoffels, V.M. et al. (2000) Dev Biol 224, 263-74.
  7. Marra, A.N. and Wingert, R.A. (2014) Cell Dev Biol 3, 1000131.
  8. Becker, M.B. et al. (2001) Mech Dev 106, 155-8.
  9. Choy, S.W. et al. (2010) Dev Dyn 239, 3204-14.
  10. Mahoney, S.E. et al. (2012) Epigenetics 7, 400-8.
  11. Bennett, K.L. et al. (2008) Cancer Res 68, 4494-9.
  12. Bennett, K.L. et al. (2009) Cancer Res 69, 9301-5.
Entrez-Gene Id
79192
Swiss-Prot Acc.
P78414
For Research Use Only. Not For Use In Diagnostic Procedures.

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