Name: ITM2A Antibody
Price: 306.00 USD
Availability: InStock

Filter:

WB

Supporting Data

REACTIVITY	H
SENSITIVITY	Endogenous
MW (kDa)	12, 39
SOURCE	Rabbit

Application Key:

WB-Western Blotting

Species Cross-Reactivity Key:

H-Human

Product Information

Product Usage Information

Application	Dilution
Western Blotting	1:1000

Storage

Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.

Protocol

Specificity / Sensitivity

ITM2A Antibody recognizes endogenous levels of total ITM2A protein.

Species Reactivity:

Human

Source / Purification

Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro9 of human ITM2A protein. Antibodies are purified by peptide affinity chromatography.

Background

Integral membrane protein 2A (ITM2A) is a type II membrane protein. ITM2A belongs to a family of membrane proteins defined by a conserved BRICHOS domain, a stretch of approximately 100 amino acids that may function as chaperone proteins (1). ITM2A, like other BRICHOS domain-containing proteins, may undergo proteolytic cleavage as it matures (2,3). BRICHOS domain-containing proteins exhibit anti-amyloidogenic activity, suggesting that these proteins may modulate formation of amyloid fibrils and oligomers (4). Aberrant amyloid formation is associated with amyloid diseases like Alzheimer’s disease. The specific function of ITM2A is unclear but it may play a redundant role in the development and function of T cells (5).

Database Links

UniProt ID: O43736

Entrez-Gene Id: 9452

Limited Uses

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For Research Use Only. Not For Use In Diagnostic Procedures.

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ITM2A Antibody #62141