KIF3B Antibody #13817
- WB
Supporting Data
| REACTIVITY | H M R Mk |
| SENSITIVITY | Endogenous |
| MW (kDa) | 85 |
| SOURCE | Rabbit |
Application Key:
- WB-Western Blotting
Species Cross-Reactivity Key:
- H-Human
- M-Mouse
- R-Rat
- Mk-Monkey
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
Storage
Protocol
Specificity / Sensitivity
Species Reactivity:
Source / Purification
Background
KIF3B binds the related kinesin family member 3A (KIF3A) and kinesin-associated protein 3 (KAP3) to form kinesin-2, an ATP-dependent heterotrimeric motor protein complex that uses plus-end-directed microtubule sliding activity to drive anterograde organelle transport (7). Studies in the zebrafish model suggest that KIF3B is required for the development and function of cilia in multiple cell types (8). Research studies show that KIF3B protein is upregulated in human hepatocellular carcinoma and that its expression is associated with poor prognosis in this cancer type (9).
- Hirokawa, N. et al. (2009) Nat Rev Mol Cell Biol 10, 682-96.
- Yu, Y. and Feng, Y.M. (2010) Cancer 116, 5150-60.
- Park, J.J. et al. (2008) Mol Endocrinol 22, 989-1005.
- Hirokawa, N. et al. (2010) Neuron 68, 610-38.
- Yoshimura, Y. et al. (2010) Mol Cell Biol 30, 2206-19.
- Hirokawa, N. and Noda, Y. (2008) Physiol Rev 88, 1089-118.
- Yamazaki, H. et al. (1995) J Cell Biol 130, 1387-99.
- Zhao, C. et al. (2012) Proc Natl Acad Sci U S A 109, 2388-93.
- Huang, X. et al. (2014) Dig Dis Sci 59, 795-806.
Limited Uses
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