Render Target: STATIC
Render Timestamp: 2025-02-18T11:07:59.687Z
Commit: 7500bcdc731e9059bbdfbdbe9e72caa896e426e8
XML generation date: 2024-11-18 16:03:16.837
Product last modified at: 2025-01-15T21:45:11.168Z
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PDP - Template Name: Polyclonal Antibody
PDP - Template ID: *******59c6464

KIFC1 Antibody #72054

Filter:
  • WB

    Supporting Data

    REACTIVITY H M R
    SENSITIVITY Endogenous
    MW (kDa) 75
    SOURCE Rabbit
    Application Key:
    • WB-Western Blotting 
    Species Cross-Reactivity Key:
    • H-Human 
    • M-Mouse 
    • R-Rat 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, and 50% glycerol. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    KIFC1 Antibody recognizes endogenous levels of total KIFC1 protein.

    Species Reactivity:

    Human, Mouse, Rat

    Source / Purification

    Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ala668 of human KIFC1 protein. Antibodies are purified by peptide affinity chromatography.

    Background

    Kinesin superfamily proteins (KIFs) are molecular motors that drive directional, microtubule-dependent intracellular transport of membrane-bound organelles and other macromolecules (e.g., proteins, nucleic acids). The intracellular transport functions of KIFs are fundamentally important for a variety of cellular functions, including mitotic and meiotic division, motility/migration, hormone and neurotransmitter release, and differentiation (1-4). Disruptions to KIF-mediated intracellular transport have been linked with a variety of pathologies, ranging from tumorigenesis to defects in higher order brain function such as learning and memory (4-6).

    Kinesin family member C1 (KIFC1/HSET) is a minus-end-directed KIF involved in the processing and movement of early endocytic vesicles (7,8), as well as microtubule cross-linking and spindle assembly (9,10).
    For Research Use Only. Not For Use In Diagnostic Procedures.
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