Render Target: STATIC
Render Timestamp: 2024-11-01T09:56:16.659Z
Commit: 23cb9f61fe67e1e9093fd644a533c4ff516a6463
XML generation date: 2024-09-20 06:21:56.560
Product last modified at: 2024-10-04T18:30:08.166Z
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PDP - Template Name: Polyclonal Antibody
PDP - Template ID: *******59c6464

LACTB Antibody #25498

Filter:
  • WB

    Supporting Data

    REACTIVITY H M R Mk
    SENSITIVITY Endogenous
    MW (kDa) 54
    SOURCE Rabbit
    Application Key:
    • WB-Western Blotting 
    Species Cross-Reactivity Key:
    • H-Human 
    • M-Mouse 
    • R-Rat 
    • Mk-Monkey 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    LACTB Antibody recognizes endogenous levels of total LACTB protein.

    Species Reactivity:

    Human, Mouse, Rat, Monkey

    Source / Purification

    Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human LACTB protein. Antibodies are purified by protein A and peptide affinity chromatography.

    Background

    LACTB is a serine beta-lactamase-like protein that is most prominently expressed in skeletal muscle, heart and liver (1). It contains an amino-terminal transmembrane domain and is localized to the mitochondrial intermembrane space, where it is polymerized into stable filaments that promote intramitochondrial membrane organization and micro-compartmentalization (2). Studies in multiple breast cancer cell types have shown that LACTB can function as a tumor suppressor by promoting decreased levels of phosphatidylserine decarboxylase (PISD), leading to reduced cell proliferation (3). In accordance with this, levels of LACTB have been shown to be downregulated in hepatocellular carcinoma and colorectal cancer and associated with poor prognosis in both (4,5).
    For Research Use Only. Not For Use In Diagnostic Procedures.
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