Render Target: STATIC
Render Timestamp: 2024-11-01T10:08:08.233Z
Commit: 23cb9f61fe67e1e9093fd644a533c4ff516a6463
XML generation date: 2024-09-20 06:18:59.467
Product last modified at: 2024-07-26T16:00:07.738Z
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PDP - Template Name: Polyclonal Antibody
PDP - Template ID: *******59c6464

LAIR-1 Antibody #87923

Filter:
  • WB
  • IP

    Supporting Data

    REACTIVITY H
    SENSITIVITY Endogenous
    MW (kDa) 40-60
    SOURCE Rabbit
    Application Key:
    • WB-Western Blotting 
    • IP-Immunoprecipitation 
    Species Cross-Reactivity Key:
    • H-Human 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000
    Immunoprecipitation 1:100

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    LAIR-1 Antibody recognizes endogenous levels of total LAIR-1 protein.

    Species Reactivity:

    Human

    Source / Purification

    Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxyterminus of human LAIR-1 protein. Antibodies are purified by protein A and peptide affinity chromatography.

    Background

    LAIR-1 is an inhibitory receptor that belongs to the Immunoglobulin superfamily. It has one extracellular Ig-like domain and an intracellular C-terminus with two ITIM (immunoreceptor tyrosine-based inhibitory motif) domains. It is found on peripheral mononuclear cells, including NK, T, and B cells, and is thought to play a negative regulatory role on the cytolytic function of these cells through signaling through collagen ligation (1). LAIR1 has been noted to be upregulated in renal cell carcinoma (2), and may play a role in expansion of Th17 cell populations in collagen-rich environments, such as in graft rejection tissue (3).
    For Research Use Only. Not For Use In Diagnostic Procedures.
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