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LAMA2 (F4S9K) Rabbit Monoclonal Antibody #88464

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  • WB
  • IF

    Product Specifications

    REACTIVITY H M R
    SENSITIVITY Endogenous
    MW (kDa) 344
    Source/Isotype Rabbit IgG
    Application Key:
    • WB-Western Blotting 
    • IF-Immunofluorescence 
    Species Cross-Reactivity Key:
    • H-Human 
    • M-Mouse 
    • R-Rat 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000
    Immunofluorescence (Frozen) 1:100

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    LAMA2 (F4S9K) Rabbit Monoclonal Antibody recognizes endogenous levels of total LAMA2 protein.

    Species Reactivity:

    Human, Mouse, Rat

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro1215 of human LAMA2 protein.

    Background

    Laminins are a family of proteins important for maintaining the cellular basement membrane (BM) structure and function (1). Laminins exist as heterotrimers of alpha (LAMA), beta (LAMB), and gamma (LAMC) chains. Laminins are reported to be involved in multiple biological processes, including cell adhesion, differentiation, migration, signaling, neurite outgrowth, and metastasis (2). LAMA2 is thought to be associated with the development and function of oligodendrocytes, the cortical plate, and the blood-brain barrier during embryonic and postnatal development. Aberrant expression of LAMA2 is associated with disease progression in patients with congenital muscular dystrophy type 1A (MDC1A) (3).

    Alternate Names

    LAMA2; Laminin M chain; laminin subunit alpha 2; Laminin subunit alpha-2; Laminin-12 subunit alpha; Laminin-2 subunit alpha; Laminin-4 subunit alpha; laminin, alpha 2; LAMM; MDC1A; Merosin heavy chain; mutant laminin subunit alpha 2

    For Research Use Only. Not for Use in Diagnostic Procedures.
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