Render Target: STATIC
Render Timestamp: 2024-12-13T11:33:03.069Z
Commit: 611277b6de3cd1bb065350b6ef8d63df412b7185
XML generation date: 2024-09-30 01:56:35.679
Product last modified at: 2024-11-04T15:00:09.215Z
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PDP - Template Name: Monoclonal Antibody
PDP - Template ID: *******c5e4b77
R Recombinant
Recombinant: Superior lot-to-lot consistency, continuous supply, and animal-free manufacturing.

LAMTOR3/MAPKSP1 (D38G5) Rabbit mAb #8168

Filter:
  • WB

    Supporting Data

    REACTIVITY
    SENSITIVITY Endogenous
    MW (kDa) 14
    Source/Isotype Rabbit IgG
    Application Key:
    • WB-Western Blotting 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    LAMTOR3/MAPKSP1 (D38G5) Rabbit mAb recognizes endogenous levels of total LAMTOR3/MAPKSP1 protein. This antibody may cross-react with LAMTOR1/C11orf59 and LAMTOR2/ROBLD3.

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Val16 of human LAMTOR3/MAPKSP1 protein.

    Background

    mTORC1 kinase complex is a critical component in the regulation of cell growth (1,2). Its activity is modulated by energy levels, growth factors, and amino acids (3,4). The four related GTPases, RagA, RagB, RagC, and RagD, have been shown to interact with raptor in mTORC1 (1,2). These interactions are both necessary and sufficient for mTORC1 activation in response to amino acid signals (1,2). A protein complex consisting of LAMTOR1/C11orf59, LAMTOR2/ROBLD3, and LAMTOR3/MAPKSP1 has been identified to interact with and recruit the four Rag GTPases to the surface of lysosomes (5).
    For Research Use Only. Not For Use In Diagnostic Procedures.
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