Render Target: STATIC
Render Timestamp: 2025-03-19T10:50:40.747Z
Commit: 779953b12a5930618aae6aca7c87fb286faeb1d7
XML generation date: 2025-03-07 13:17:25.848
Product last modified at: 2025-01-01T09:01:59.339Z
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PDP - Template Name: Polyclonal Antibody
PDP - Template ID: *******59c6464

Lloviu Virus VP35 Antibody #72219

Filter:
  • WB

    Supporting Data

    REACTIVITY Vir
    SENSITIVITY Endogenous
    MW (kDa) 40
    SOURCE Rabbit
    Application Key:
    • WB-Western Blotting 
    Species Cross-Reactivity Key:
    • Vir-Virus 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, and 50% glycerol. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    Lloviu Virus VP35 Antibody recognizes endogenous levels of total Lloviu virus VP35 protein.

    Species Reactivity:

    Virus

    Source / Purification

    Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro47 of Lloviu virus VP35 protein. Antibodies are purified by peptide affinity chromatography.

    Background

    The Lloviu virus (LLOV) is a pathogenic filovirus identified in bat populations in southern Europe (1-3). It belongs to the Filoviridae family, members of which (e.g., Ebola, Marburg) are known to cause fatal hemorrhagic diseases in primates, including humans (4). Transcription and replication of filoviruses requires formation of a ribonucleoprotein (RNP) complex, composed of nucleoprotein (NP) together with viral polymerase enzymes and cofactors. Viral Protein 35 (VP35), a polymerase cofactor, is one of the key components of the RNP complex in filoviruses (5). In addition to its role in promoting viral replication, research studies in both bat and human cells have shown that Lloviu virus VP35 can suppress the host innate immune response to viral infection, in part through suppression of the interferon response (6). These immunosuppressive functions of Lloviu virus VP35 are consistent with those observed for VP35 homologs in other filovirus species (7,8).
    For Research Use Only. Not For Use In Diagnostic Procedures.
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