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LSm2 Antibody #8498

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  • WB

Inquiry Info. # 8498

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    Product Specifications

    REACTIVITY H M R Mk
    SENSITIVITY Endogenous
    MW (kDa) 11
    SOURCE Rabbit
    Application Key:
    • WB-Western Blotting 
    Species Cross-Reactivity Key:
    • H-Human 
    • M-Mouse 
    • R-Rat 
    • Mk-Monkey 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    LSm2 Antibody recognizes endogenous levels of total LSm2 protein.

    Species Reactivity:

    Human, Mouse, Rat, Monkey

    Source / Purification

    Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Val77 of human LSm2 protein. Antibodies are purified by protein A and peptide affinity chromatography.

    Background

    LSm proteins are members of an ancient family of RNA binding proteins that function in RNA metabolism (1,2). Two LSm complexes or rings have been identified based on protein composition: LSm1-7 and LSm2-8 (1). The cytoplasmic LSm1-7 complex is involved in mRNA degradation (3) while the LSm2-8 ring is required for pre-tRNA and rRNA maturation (4,5) and regulation of pre-mRNA splicing through its association with U6 snRNA (6). Recent studies show that LSm2-8 complex functions in the biogenesis of telomerase RNA (1).

    Alternate Names

    C6orf28; G7B; LSM2; LSM2 homolog, U6 small nuclear RNA and mRNA degradation associated; LSM2 homolog, U6 small nuclear RNA associated; LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae); LSM2 U6 small nuclear RNA and mRNA degradation associated; Protein G7b; Small nuclear ribonuclear protein D homolog; snRNP; snRNP core Sm-like protein Sm-x5; U6 snRNA-associated Sm-like protein LSm2; YBL026W

    For Research Use Only. Not for Use in Diagnostic Procedures.
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