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LTA4H (F9F5O) Rabbit Monoclonal Antibody

LTA4H (F9F5O) Rabbit Monoclonal Antibody #38877

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Product Specifications

REACTIVITY	H
SENSITIVITY	Endogenous
MW (kDa)	69
Source/Isotype	Rabbit IgG

Application Key:

WB-Western Blotting

Species Cross-Reactivity Key:

H-Human

Product Information

Product Usage Information

Application	Dilution
Western Blotting	1:1000

Storage

Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

Protocol

Specificity / Sensitivity

LTA4H (F9F5O) Rabbit Monoclonal Antibody recognizes endogenous levels of total LTA4H protein.

Species Reactivity:

Human

Source / Purification

Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Val72 of human LTA4H protein.

Background

Leukotrienes (LTs) are a group of biologically active lipid mediators (LTA4, LTB4, LTC4, LTD4, and LTE4), which are secreted from multiple cell types and play a critical role in recruiting leukocytes and other immune cells to sites of inflammation in the periphery. The enzyme leukotriene A4 hydrolase (LTA4H) classically functions intracellularly, primarily within myeloid cells, to convert LTA4 into pro-inflammatory lipid mediator LTB4 (1). But LTA4H is a bifunctional zinc metalloenzyme that comprises both epoxide hydrolase and aminopeptidase activity, exerted by two overlapping catalytic sites (2). The aminopeptidase function of LTA4H is responsible for the tripeptide Pro-Gly-Pro (PGP) degradation. This suggests that LTA4H may have two opposing roles in the inflammation regulation: on the one hand, LTA4H is responsible for the biosynthesis of the pro-inflammatory, neutrophil chemotactic lipid mediator LTB4, and on the other hand, it degrades and inactivates the chemotactic tripeptide PGP (3). More recently, LTA4H expression has been found in healthy mouse neurons, and inhibition of LTA4H in aged mice improved hippocampal-dependent memory. In addition, LTA4H plasma levels are increased in both aging and Alzheimer’s disease and correlated with cognitive impairment (4).

Alternate Names

Leukotriene A-4 hydrolase; Leukotriene A(4) hydrolase; leukotriene A4 hydrolase; LKHA4; LTA-4 hydrolase; LTA4; LTA4H; testicular secretory protein Li 27

Database Links

UniProt ID: P09960

Entrez-Gene Id: 4048

Limited Uses

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For Research Use Only. Not for Use in Diagnostic Procedures.

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