Render Target: STATIC
Render Timestamp: 2025-02-18T11:09:33.338Z
Commit: 7500bcdc731e9059bbdfbdbe9e72caa896e426e8
XML generation date: 2024-08-01 15:27:30.763
Product last modified at: 2025-01-01T09:01:34.482Z
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PDP - Template Name: Polyclonal Antibody
PDP - Template ID: *******59c6464

Lu/BCAM Antibody #92189

Filter:
  • WB

    Supporting Data

    REACTIVITY H
    SENSITIVITY Endogenous
    MW (kDa) 85, 88
    SOURCE Rabbit
    Application Key:
    • WB-Western Blotting 
    Species Cross-Reactivity Key:
    • H-Human 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    Lu/BCAM Antigody recognizes endogenous levels of total Lu/BCAM protein.

    Species Reactivity:

    Human

    Source / Purification

    Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ala587 of human Lu/BCAM protein. Antibodies are purified by protein A and peptide affinity chromatography.

    Background

    Lu/BCAM (CD239) is a transmembrane cell adhesion molecule belonging to the immunoglobulin superfamily (1). The protein mediates cell adhesion by binding to basal membrane laminin α5, and cell surface integrin α4β1 (2,3). The interaction between Lu/BCAM and its ligands can be activated via phosphorylation in its cytoplasmic tail by either PKA or Akt signaling (4,5). In sickle cell disease, Lu/BCAM was reported to promote abnormal red blood cell adhesion to endothelium, and thus may contribute to vaso-occlusive crisis (6). Overexpression of Lu/BCAM has also been reported in breast cancer, skin cancer, colon cancer, and ovarian cancer (7, 8). Antibody-drug conjugates targeting Lu/BCAM on tumor cells surface has been proposed as a potential approach for cancer therapy (8).
    For Research Use Only. Not For Use In Diagnostic Procedures.
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