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LY6G6D (F7X3A) Rabbit Monoclonal Antibody #24332

Filter:
  • WB
  • F

    Product Specifications

    REACTIVITY H
    SENSITIVITY Endogenous
    MW (kDa) 14-24
    Source/Isotype Rabbit IgG
    Application Key:
    • WB-Western Blotting 
    • F-Flow Cytometry 
    Species Cross-Reactivity Key:
    • H-Human 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000
    Simple Western™ 1:50 - 1:250
    Flow Cytometry (Fixed/Permeabilized) 1:800 - 1:3200
    Flow Cytometry (Live) 1:100 - 1:400

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    LY6G6D (F7X3A) Rabbit Monoclonal Antibody recognizes endogenous levels of total LY6G6D protein.

    Species Reactivity:

    Human

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with recombinant protein specific to the amino terminus of human LY6G6D protein.

    Background

    Lymphocyte antigen 6 family member G6D (LY6G6D) is a member of the lymphocyte antigen 6 (Ly-6) superfamily that is located within the MHC class III region of chromosome 6 (1). LY6G6D is anchored to the cell membrane by glycosylphosphatidylinositol (GPI) and is believed to play a role in filopodia formation, but its exact function is not fully understood (2,3). LY6G6D is overexpressed in colorectal cancer tumors but has minimal expression in healthy tissue, making it an attractive target for immunotherapies (4). Indeed, bispecific T cell engagers targeting LY6G6D and CD3 have shown initial promise in clearing colorectal tumors in mice (5,6).

    Alternate Names

    C6orf23; G6D; LY6-D; LY66D; LY6G6D; lymphocyte antigen 6 complex G6D; Lymphocyte antigen 6 complex locus protein G6d; lymphocyte antigen 6 complex, locus G6D; lymphocyte antigen 6 family member G6D; lymphocyte antigen-6 G6D; megakaryocyte-enhanced gene transcript 1; Megakaryocyte-enhanced gene transcript 1 protein; MEGT1; MGC150334; NG25; O95868; OTTHUMP00000070738; Protein Ly6-D

    For Research Use Only. Not for Use in Diagnostic Procedures.
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