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LYVE-1 (F7W7U) Rabbit Monoclonal Antibody #24084

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  • IHC

    Product Specifications

    REACTIVITY H
    SENSITIVITY Endogenous
    MW (kDa) 60-70
    Source/Isotype Rabbit IgG
    Application Key:
    • WB-Western Blotting 
    • IHC-Immunohistochemistry 
    Species Cross-Reactivity Key:
    • H-Human 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000
    Immunohistochemistry (Paraffin) 1:800 - 1:3200

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    LYVE-1 (F7W7U) Rabbit Monoclonal Antibody recognizes endogenous levels of total LYVE-1 protein.

    Species Reactivity:

    Human

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with recombinant protein specific to the amino terminus of human LYVE-1 protein.

    Background

    Lymphatic vessel endothelial hyaluronan receptor 1 (LYVE-1), also known as extracellular link domain-containing protein 1 (XLKD1), is a type I integral membrane glycoprotein. LYVE-1 is a CD44 homolog found primarily on lymphatic endothelial cells, but has also been described on hepatic blood sinusoidal endothelia, embryonic blood vessels, Kupffer cells, the islets of Langerhans, cortical neurons, and renal epithelium (1-3). LYVE-1 acts as a receptor for hyaluronan, and plays a role in hyaluronan transport and turnover (4-7). LYVE-1 also mediates the docking and entry of dendritic cells to lymphatic vessels through selective adhesion to hyaluronan in the leukocyte surface glycocalyx (8). Several studies have demonstrated the utility of LYVE-1 as a marker for lymphoid tissues and lymphangiogenesis (9,10).

    Alternate Names

    cell surface retention sequence binding protein-1; Cell surface retention sequence-binding protein 1; CRSBP-1; CRSBP1; extracellular link domain containing 1; extracellular link domain-containing 1; Extracellular link domain-containing protein 1; HAR; Hyaluronic acid receptor; lymphatic vessel endothelial hyaluronan receptor 1; Lymphatic vessel endothelial hyaluronic acid receptor 1; LYVE-1; LYVE1; XLKD1

    For Research Use Only. Not for Use in Diagnostic Procedures.
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