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MACC1 (D2K7V) Rabbit Monoclonal Antibody #86290

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  • WB

    Product Specifications

    REACTIVITY H
    SENSITIVITY Endogenous
    MW (kDa) 97
    Source/Isotype Rabbit IgG
    Application Key:
    • WB-Western Blotting 
    Species Cross-Reactivity Key:
    • H-Human 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    MACC1 (D2K7V) Rabbit Monoclonal Antibody recognizes endogenous levels of total MACC1 protein.

    Species Reactivity:

    Human

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro442 of human MACC1 protein.

    Background

    The gene encoding metastasis-associated in colon cancer-1 (MACC1) was identified based on its overexpression in metastatic colon carcinoma (1), and was later shown to be overexpressed in multiple human cancers, including hepatocellular carcinoma, gastric cancer, head and neck cancer, and breast cancer (2-4). MACC1 regulates HGF/MET and β-catenin signaling, resulting in increased proliferation, migration and invasion, and initiation of the epithelial-mesenchymal transition (EMT) (2). Researchers have shown that MACC1 can be used as a prognostic indicator in solid tumors, and that it has potential as a therapeutic target (5).

    Alternate Names

    7A5; MACC1; MACC1, MET transcriptional regulator; MET transcriptional regulator MACC1; metastasis associated in colon cancer 1; Metastasis-associated in colon cancer protein 1; putative binding protein 7a5; SH3 domain-containing protein 7a5; SH3BP4L

    For Research Use Only. Not for Use in Diagnostic Procedures.
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