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MAL (F6X1A) Rabbit Monoclonal Antibody #20017

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  • WB

    Product Specifications

    REACTIVITY H M R
    SENSITIVITY Endogenous
    MW (kDa) 17
    Source/Isotype Rabbit IgG
    Application Key:
    • WB-Western Blotting 
    Species Cross-Reactivity Key:
    • H-Human 
    • M-Mouse 
    • R-Rat 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    MAL (F6X1A) Rabbit Monoclonal Antibody recognizes endogenous levels of total MAL protein.

    Species Reactivity:

    Human, Mouse, Rat

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro13 of human MAL protein.

    Background

    Myelin and lymphocyte protein (MAL) is a 17 kDa protein resident of glycosphingolipid and cholesterol-enriched microdomains (1). MAL expression is restricted to human T cells, polarized epithelial cells, and myelin-forming cells (2). In the nervous system, it is crucial for myelin formation, maintenance, and function, particularly in oligodendrocytes and Schwann cells (3). In lymphocytes, MAL is involved in signal transduction and the formation of immunological synapses. Additionally, MAL is involved in various cellular processes, such as protein sorting, membrane trafficking, and even tumorigenesis (1,4).

    Alternate Names

    MAL; mal, T cell differentiation protein; mal, T-cell differentiation protein; MVP17; Myelin and lymphocyte protein; P21145; T-cell differentiation protein MAL; T-lymphocyte maturation-associated protein; VIP17

    For Research Use Only. Not for Use in Diagnostic Procedures.
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