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MAP1B (E8S8R) Rabbit Monoclonal Antibody #90604

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  • WB
  • IP

    Product Specifications

    REACTIVITY H M R
    SENSITIVITY Endogenous
    MW (kDa) 270
    Source/Isotype Rabbit IgG
    Application Key:
    • WB-Western Blotting 
    • IP-Immunoprecipitation 
    Species Cross-Reactivity Key:
    • H-Human 
    • M-Mouse 
    • R-Rat 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000
    Immunoprecipitation 1:50

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

    For a carrier free (BSA and azide free) version of this product see product #48721.

    Protocol

    Specificity / Sensitivity

    MAP1B (E8S8R) Rabbit Monoclonal Antibody recognizes endogenous levels of total MAP1B protein.

    Species Reactivity:

    Human, Mouse, Rat

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Val1570 of human MAP1B protein.

    Background

    Microtubule-associated protein 1B (MAP1B) is a member of the high molecular weight microtubule binding phosphoprotein family, along with MAP1A (1). MAP1B is highly expressed in neurons, predominantly during development, where it regulates axonal guidance and elongation through its influence on microtubule dynamics (1,2). In mature neurons, MAP1B plays a role in regulation and structure of dendritic spines in glutamatergic synapses. MAP1B deficient neurons have been shown to display structural presynaptic deficiencies, including a decrease in density at synaptic terminals and disruption of synaptic vesicle fusion events (2). Mutations in MAP1B have been linked to developmental disorders affecting cognitive ability through a deficit in white matter and compromised axons (3).

    Alternate Names

    DKFZp686E1099; DKFZp686F1345; FLJ38954; FUTSCH; MAP-1B; MAP1 light chain LC1; MAP1B; MAP1B heavy chain; MAP5; microtubule associated protein 1B; Microtubule-associated protein 1B; PPP1R102; protein phosphatase 1, regulatory subunit 102; PVNH9

    For Research Use Only. Not for Use in Diagnostic Procedures.
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