Render Target: STATIC
Render Timestamp: 2024-12-02T12:18:45.114Z
Commit: cd2fae6ca3f811b1ddb1df24ac291ed56d5d501b
XML generation date: 2024-08-01 15:28:37.075
Product last modified at: 2024-06-27T13:37:02.063Z
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PDP - Template Name: Polyclonal Antibody
PDP - Template ID: *******59c6464

MAP1S Antibody #54232

Filter:
  • WB

    Supporting Data

    REACTIVITY M R
    SENSITIVITY Endogenous
    MW (kDa) 125, 142
    SOURCE Rabbit
    Application Key:
    • WB-Western Blotting 
    Species Cross-Reactivity Key:
    • M-Mouse 
    • R-Rat 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    MAP1S Antibody recognizes endogenous levels of total MAP1S protein.

    Species Reactivity:

    Mouse, Rat

    Source / Purification

    Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Arg499 of mouse MAP1S protein. Antibodies are purified by peptide affinity chromatography.

    Background

    MAP1S is a member of the microtubule-associated protein (MAP) family. There are at least ten proteins in the MAP family, including MAP1A, MAP1B, MAP1S, MAP2, MAP6, MAP7, MAP9, Tau, DCLK, and DCX. MAP1 subfamily members express predominantly in brain cells regulating several physiological processes in cells, including cytoskeleton regulation that, in some cases are energy-dependent, including the autophosphorylation and phosphorylation of other MAP family members, and other cytoskeletal proteins (1,2). MAP1 family members have been identified as high-molecular-weight proteins consisting of the full-length (FL), at least one heavy chain (HC), one light chain (LC), and, in some members short chains (SC) (2,3). The FL-MAP1S is formed by the HC and LC, forming the active MAP1S complex. The LC binds, bundles, and stabilizes microtubules, and the HC regulates LC activity (2). MAP1S also interacts with Nemitin (neuronal enriched MAP interacting protein), enhancing cytoskeleton regulation (4).

    MAP1S contributes to mitochondria stabilization by interacting with mitochondrion-associated leucine-rich PPR-motif containing protein (LRPPRC). MAP1S regulates ubiquitination processes like autophagosome biogenesis and protein clearance. These processes are MAP1S isoform-specific (5). An increased level of MAP1S enhances autophagy to remove p62-associated aggresomes and dysfunctional organelles that trigger DNA double-strand breaks and genome instability (6).
    For Research Use Only. Not For Use In Diagnostic Procedures.
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