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W IP         H Mk
101 Rabbit

Product Usage Information

Storage: Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.

Specificity / Sensitivity

MAP4K3 Antibody recognizes endogenous levels of total MAP4K3 protein.

Source / Purification

Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Gly407 of human MAP4K3 protein. Antibodies are purified by protein A and peptide affinity chromatography.

The mTORC1 kinase complex is a critical regulator of cell growth (1,2). Its activity is modulated by growth factors and nutrients including amino acids (1,2). MAP4K3 is a mediator between nutrient signal and mTORC1 (1). Research studies suggest that amino acid sufficiency leads to the phosphorylation of Ser170 on MAP4K3, which activates mTORC1 (3).

1.  Findlay, G.M. et al. (2007) Biochem J 403, 13-20.

2.  Sancak, Y. et al. (2008) Science 320, 1496-501.

3.  Yan, L. et al. (2010) Mol Cell 37, 633-42.

Entrez-Gene Id 8491
Swiss-Prot Acc. Q8IVH8

For Research Use Only. Not For Use In Diagnostic Procedures.
Cell Signaling Technology is a trademark of Cell Signaling Technology, Inc.

MAP4K3 Antibody