Render Target: STATIC
Render Timestamp: 2025-03-14T11:17:34.500Z
Commit: a619ae74f66dae0f27639e88da12bcf600e46428
XML generation date: 2025-03-07 13:16:03.981
Product last modified at: 2025-01-01T09:01:50.898Z
Cell Signaling Technology Logo
1% for the planet logo
PDP - Template Name: Polyclonal Antibody
PDP - Template ID: *******59c6464

MB21D2 Antibody #74981

Filter:
  • WB
  • IP

    Supporting Data

    REACTIVITY H
    SENSITIVITY Endogenous
    MW (kDa) 56
    SOURCE Rabbit
    Application Key:
    • WB-Western Blotting 
    • IP-Immunoprecipitation 
    Species Cross-Reactivity Key:
    • H-Human 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000
    Immunoprecipitation 1:200

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    MB21D2 Antibody recognizes endogenous levels of total MB21D2 protein. This antibody detects a 180 kDa band of unknown origin.

    Species Reactivity:

    Human

    Source / Purification

    Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human MB21D2 protein. Antibodies are purified by protein A and peptide affinity chromatography.

    Background

    Mab-21 domain-containing protein 2 (MB21D2), also known as C3orf59, belongs to a protein family of cGAS/DncV-like nucleotidyltransferase (CD-NTase) enzymes involved in a variety of cellular processes, including cell survival, proliferation, and migration (3). MB21D2 is an intracellular E-cadherin binder that carries a recurrent Q311E mutation (1,4). Both wild-type (WT) and Q311E mutant MB21D2 have been identified as being frequently overexpressed in lung, head, and neck cancers, and may mediate pro-oncogenic activities by promoting epithelial-mesenchymal transition (EMT)/cancer stemness (2-4).
    For Research Use Only. Not For Use In Diagnostic Procedures.
    Cell Signaling Technology is a trademark of Cell Signaling Technology, Inc.
    All other trademarks are the property of their respective owners. Visit our Trademark Information page.