MCF2/Dbl Antibody #2089
- WB
Supporting Data
| REACTIVITY | H M R |
| SENSITIVITY | Endogenous |
| MW (kDa) | 100 |
| SOURCE | Rabbit |
Application Key:
- WB-Western Blotting
Species Cross-Reactivity Key:
- H-Human
- M-Mouse
- R-Rat
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
Storage
Protocol
Specificity / Sensitivity
Species Reactivity:
Source / Purification
Background
Dbl interacts with ezrin, a member of the ezrin/radixin/moesin (ERM) family of proteins that links the plasma membrane to the actin cytoskeleton. Dbl interacts with ezrin in lipid microdomains, which leads to Cdc42 activation and the regulation of processes such as filopodia formation and cell polarity (5,6). Dbl localization and biological activities are regulated in part by phosphatidylinositol 3-kinase (PI3K) (7). Dbl is also involved in cell survival and inhibits apoptosis through induction of Akt phosphorylation at Thr308 (8).
- Zheng, Y. (2001) Trends Biochem Sci 26, 724-32.
- Ron, D. et al. (1988) EMBO J 7, 2465-73.
- Hart, M.J. et al. (1991) Nature 354, 311-4.
- Kamynina, E. et al. (2007) Mol Cell Biol 27, 1809-22.
- Batchelor, C.L. et al. (2007) Cell Cycle 6, 353-63.
- Prag, S. et al. (2007) Mol Biol Cell 18, 2935-48.
- Vanni, C. et al. (2006) Cell Cycle 5, 2657-65.
- Morley, S. et al. (2007) Cell Signal 19, 211-8.
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