Render Target: STATIC
Render Timestamp: 2024-12-02T11:05:25.494Z
Commit: cd2fae6ca3f811b1ddb1df24ac291ed56d5d501b
XML generation date: 2024-08-01 15:28:38.465
Product last modified at: 2024-06-24T15:15:07.646Z
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PDP - Template Name: Polyclonal Antibody
PDP - Template ID: *******59c6464

Mfsd2a Antibody #57755

Filter:
  • WB

    Supporting Data

    REACTIVITY M
    SENSITIVITY Endogenous
    MW (kDa) 50-60
    SOURCE Rabbit
    Application Key:
    • WB-Western Blotting 
    Species Cross-Reactivity Key:
    • M-Mouse 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    Mfsd2a Antibody recognizes endogenous levels of total Mfsd2a protein.

    Species Reactivity:

    Mouse

    The antigen sequence used to produce this antibody shares 100% sequence homology with the species listed here, but reactivity has not been tested or confirmed to work by CST. Use of this product with these species is not covered under our Product Performance Guarantee.

    Species predicted to react based on 100% sequence homology:

    Rat

    Source / Purification

    Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of mouse Mfsd2a protein. Antibodies are purified by peptide affinity chromatography.

    Background

    Mfsd2a is a sodium-dependent lysophosphatidylcholine symporter (1). It regulates lipid metabolism, growth and development, and motor function (2). It transports lysophosphatidylcholines consisting of omega-3 fatty acid docosahexaenoic acid (DHA) or other long-chain fatty acids. Mfsd2a was shown to be critical for the brain to take up DHA from plasma (3). Furthermore, Mfsd2a is required for the blood-brain barrier (BBB) formation and function (4). Lipids transported into endothelial cells in the central nervous system by Mfsd2a form a lipid environment essential to maintain BBB integrity (5).
    For Research Use Only. Not For Use In Diagnostic Procedures.
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