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Render Timestamp: 2024-10-15T09:48:39.055Z
Commit: 56767fe525c928647c8401233a175d0d607d385d
XML generation date: 2024-08-01 15:30:11.651
Product last modified at: 2024-09-19T18:30:08.914Z
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PDP - Template Name: Polyclonal Antibody
PDP - Template ID: *******59c6464
  1. Products /
  2. Primary Antibodies /
  3. Miro2 Antibody

Miro2 Antibody #14016

Filter:
  • WB

    Supporting Data

    REACTIVITY H Mk
    SENSITIVITY Endogenous
    MW (kDa) 80
    SOURCE Rabbit
    Application Key:
    • WB-Western Blotting 
    Species Cross-Reactivity Key:
    • H-Human 
    • Mk-Monkey 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    Miro2 Antibody recognizes endogenous levels of total Miro2 protein.

    Species Reactivity:

    Human, Monkey

    Source / Purification

    Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Gly452 of human Miro2 protein. Antibodies are purified by protein A and peptide affinity chromatography.

    Background

    Mitochondrial Rho GTPase 1 (Miro1, RHOT1) and mitochondrial Rho GTPase 2 (Miro2, RHOT2) are atypical Ras GTPase proteins that localize to the outer mitochondrial membrane (1,2). These evolutionarily conserved proteins contain GTP-binding domains and a pair of calcium-binding EF hand domains (1,2). Research studies indicate that Miro1 and Miro2 function in the axonal transport of mitochondria in neurons (2). Both Miro proteins play an essential role in mitochondrial trafficking by attaching mitochondria to essential motor and adaptor proteins (3). Miro GTPase proteins that are anchored to the outer mitochondrial membrane interact with kinesin-binding proteins TRAK1 and TRAK2 to provide a link between mitochondria to microtubules (4). Increased levels of synaptic calcium appears to inhibit mitochondrial trafficking mediated by Miro, suggesting a role for the EF hand as a calcium sensor (5).

    Database Links

    UniProt ID: Q8IXI1


    Entrez-Gene Id: 89941


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    For Research Use Only. Not For Use In Diagnostic Procedures.
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