Render Target: STATIC
Render Timestamp: 2024-10-14T09:50:23.352Z
Commit: 56767fe525c928647c8401233a175d0d607d385d
XML generation date: 2024-06-11 16:01:17.378
Product last modified at: 2024-09-18T21:45:07.431Z
1% for the planet logo
PDP - Template Name: Antibody Sampler Kit
PDP - Template ID: *******4a3ef3a

Mouse Reactive Senescence Associated Secretory Phenotype (SASP) Antibody Sampler Kit #85741

    Product Information

    Product Description

    The Mouse Reactive Senescence Associated Secretory Phenotype (SASP) Antibody Sampler Kit provides an economical means of detecting multiple components of the SASP in mouse samples. The kit includes enough antibodies to perform two western blot experiments with each primary antibody.

    Specificity / Sensitivity

    Each antibody in the Mouse Reactive Senescence Associated Secretory Phenotype (SASP) Antibody Sampler Kit detects endogenous levels of its target protein. RANTES Antibody (Rodent Specific) detects transfected levels of rodent RANTES.

    Source / Purification

    Monoclonal antibodies are produced by immunizing animals with recombinant human IL-1β protein, recombinant mouse TNF-α protein, recombinant mouse IL-6 protein, a synthetic peptide corresponding to residues surrounding Cys75 of mouse MCP-1 protein, or a synthetic peptide corresponding to residues surrounding Pro117 of human MMP-2 protein. Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues at the carboxyl terminus of rodent RANTES protein or corresponding to residues surrounding Gly196 of murine PAI-1 protein. Polyclonal antibodies are purified by peptide affinity chromatography.

    Background

    Senescence is characterized by stable stress-induced proliferative arrest and resistance to mitogenic stimuli, as well as the secretion of proteins such as cytokines, growth factors, and proteases. These secreted proteins comprise the senescence-associated secretory phenotype (SASP). Senescent cells are thought to accumulate as an organism ages, and contribute to age-related diseases, including cancer, through promotion of inflammation and disruption of normal cellular function (1,2). The composition of the SASP varies, and SASP components can be either beneficial or deleterious in human disease, depending on the context (3).
    The Mouse Reactive Senescence Associated Secretory Phenotype (SASP) Antibody Sampler Kit provides a collection of antibodies to various SASP components, including TNF-α, interleukin-6 (IL-6), the multifunctional cytokine IL-1β, the chemokines RANTES/CCL5 and MCP-1, the matrix metalloprotease MMP-2, and the serine-protease inhibitor PAI-1.
    For Research Use Only. Not For Use In Diagnostic Procedures.
    Cell Signaling Technology is a trademark of Cell Signaling Technology, Inc.
    XP is a registered trademark of Cell Signaling Technology, Inc.
    All other trademarks are the property of their respective owners. Visit our Trademark Information page.