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4386
MTSS1 (N747) Antibody

MTSS1 (N747) Antibody #4386

This product is discontinued

We recommend the following alternatives

  • WB
  • IP
  • IHC
  • IF
H R XP
Storage:

Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.

MTSS1 (N747) Antibody detects endogenous levels of total MTSS1 protein.

Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to amino acids surrounding Asn747 of human MTSS1. Antibodies are purified by peptide affinity chromatography.

Metastasis suppressor 1 (MTSS1) is a multi-functional scaffold protein that was initially discovered using a differential display technique that identified proteins missing from bladder cancer cell lines (1,2). MTSS1 (also known as Missing in Metastasis or MIM) is a cytoskeletal remodeling protein that contains a C-terminal WH2 actin-binding motif (1,3). Presence of an IMD (IRSp53/MIM homology) domain allows MTSS1 to induce F-actin bundling and filopodia formation in cells (4). MTSS1 binds to and activates Rac, a protein known to promote the formation of filopodia and lamellipodia (5). The receptor tyrosine phosphatase δ (PTPRD) is associated with MTSS1 and is required for MTSS1-dependent cytoskeletal change (6,7). MTSS1 is a SHH responsive gene that can help regulate GLI-dependent transcriptional activity (8).

  1. Lee, Y.G. et al. Neoplasia 4, 291-4.
  2. Machesky, L.M. and Johnston, S.A. (2007) J Mol Med 85, 569-76.
  3. Mattila, P.K. et al. (2003) J Biol Chem 278, 8452-9.
  4. Yamagishi, A. et al. (2004) J Biol Chem 279, 14929-36.
  5. Bompard, G. et al. (2005) J Cell Sci 118, 5393-403.
  6. Woodings, J.A. et al. (2003) Biochem J 371, 463-71.
  7. Gonzalez-Quevedo, R. et al. (2005) J Cell Biol 168, 453-63.
  8. Callahan, C.A. et al. (2004) Genes Dev 18, 2724-9.
Entrez-Gene Id
9788
Swiss-Prot Acc.
O43312
For Research Use Only. Not For Use In Diagnostic Procedures.

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