NALP1 (E3F2U) Rabbit Monoclonal Antibody #56719
- WB
- IP
Product Specifications
| REACTIVITY | H |
| SENSITIVITY | Endogenous |
| MW (kDa) | 165 |
| Source/Isotype | Rabbit IgG |
Application Key:
- WB-Western Blotting
- IP-Immunoprecipitation
Species Cross-Reactivity Key:
- H-Human
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
| Immunoprecipitation | 1:100 |
Storage
Protocol
Specificity / Sensitivity
Species Reactivity:
Source / Purification
Background
NALP1 is autoproteolytically processed into a large N-terminal and a small C-terminal fragment, which are non-covalently associated. Upon activation, the C-terminal is released and forms inflammasomes with other proteins (10-12).
- Bertin, J. and DiStefano, P.S. (2000) Cell Death Differ. 7, 1273-1274.
- Chu, Z.L. et al. (2001) J. Biol. Chem. 276, 9239-9245.
- Hlaing, T. et al. (2001) J. Biol. Chem. 276, 9230-9238.
- Martinon, F. et al. (2001) Curr. Biol. 11, R118-R120.
- Fritz, J.H. et al. (2006) Nat. Immunol. 7, 1250-1257.
- Martinon, F. et al. (2002) Mol. Cell 10, 417-426.
- Kummer, J.A. et al. (2007) J. Histochem. Cytochem. 55, 443-452.
- Jin, Y. et al. (2007) N. Engl. J. Med. 356, 1216-1225.
- Boyden, E.D. and Dietrich, W.F. (2006) Nat. Genet. 38, 240-244.
- D'Osualdo, A. et al. (2011) PLoS One 6, e27396.
- Robert Hollingsworth, L. et al. (2021) Nat Commun 12, 189.
- Gong, Q. et al. (2021) Nat Commun 12, 188.
Alternate Names
AIADK; CARD7; caspase recruitment domain protein 7; Caspase recruitment domain-containing protein 7; CIDED; CLR17.1; Death effector filament-forming ced-4-like apoptosis protein; DEFCAP; DEFCAP-L/S; DKFZp586O1822; JRRP; KIAA0926; MSPC; NAC; NACHT, leucine rich repeat and PYD (pyrin domain) containing 1; NACHT, leucine rich repeat and PYD containing 1; NACHT, LRR and PYD containing protein 1; NACHT, LRR and PYD domains-containing protein 1; NALP1; NLR family pyrin domain containing 1; NLR family, pyrin domain containing 1; NLRP1; Nucleotide-binding domain and caspase recruitment domain; nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 1; PP1044; SLEV1; VAMAS1
Limited Uses
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