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Dec 31st Santa Cruz will discontinue a
large number of polyclonal products as
a result of the USDA settlement that was
made public May 19th.

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REACTIVITY SENSITIVITY MW (kDa) SOURCE
42 Rabbit

Product Usage Information

Storage: Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.

Specificity / Sensitivity

Nanog Antibody (Mouse Specific) recognizes endogenous levels of total mouse nanog protein.


Source / Purification

Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues near the amino terminus of mouse nanog protein. Antibodies are purified by protein A and peptide affinity chromatography.

Nanog is a homeodomain-containing transcription factor that is essential for the maintenance of pluripotency and self renewal in embryonic stem cells (1). Nanog expression is controlled by a network of factors including Sox2 and the key pluripotency regulator Oct-4 (1). Recent advances in somatic cell reprogramming have utilized viral expression of combinations of transcription factors including nanog, Oct-4, Sox2, KLF4, c-Myc, and LIN28 (2,3).


1.  Kim, J. et al. (2008) Cell 132, 1049-61.

2.  Takahashi, K. et al. (2007) Nat Protoc 2, 3081-9.

3.  Yu, J. et al. (2007) Science 318, 1917-20.


Entrez-Gene Id 71950
Swiss-Prot Acc. Q80Z64


For Research Use Only. Not For Use In Diagnostic Procedures.
Cell Signaling Technology is a trademark of Cell Signaling Technology, Inc.

8600
Nanog Antibody (Mouse Specific)