Render Target: STATIC
Render Timestamp: 2024-10-14T09:44:09.904Z
Commit: 56767fe525c928647c8401233a175d0d607d385d
XML generation date: 2024-08-01 15:27:59.059
Product last modified at: 2024-08-19T13:45:07.967Z
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PDP - Template Name: Polyclonal Antibody
PDP - Template ID: *******59c6464

NCAM2 Antibody #64422

Filter:
  • WB

    Supporting Data

    REACTIVITY H M R
    SENSITIVITY Endogenous
    MW (kDa) 93, 140
    SOURCE Rabbit
    Application Key:
    • WB-Western Blotting 
    Species Cross-Reactivity Key:
    • H-Human 
    • M-Mouse 
    • R-Rat 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    NCAM2 Antibody recognizes endogenous levels of total NCAM2 protein. This antibody does not cross-react with NCAM1.

    Species Reactivity:

    Human, Mouse, Rat

    Source / Purification

    Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro48 of human NCAM2 protein. Antibodies are purified by peptide affinity chromatography.

    Background

    NCAM (neural cell adhesion molecule) is an adhesion glycoprotein with five extracellular immunoglobulin-like domains followed by two fibronectin type III repeats. Two NCAM paralogs (NCAM1 and NCAM2) are encoded in the mammalian genome, which encode NCAM/NCAM1 and NCAM2 proteins, respectively (1,2). As an adhesion molecule with brain-enriched expression, NCAM2 functions to drive axonal targeting, neurite branching, and synaptic development (2-4). NCAM2 is also genetically linked to Down syndrome and may play a role in neurodegenerative diseases such as Alzheimer’s disease (2,5). 
    For Research Use Only. Not For Use In Diagnostic Procedures.
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