Neurogenin 2 (D2R3D) Rabbit mAb #13144
- WB
Supporting Data
| REACTIVITY | H M R |
| SENSITIVITY | Endogenous |
| MW (kDa) | 35 |
| Source/Isotype | Rabbit IgG |
Application Key:
- WB-Western Blotting
Species Cross-Reactivity Key:
- H-Human
- M-Mouse
- R-Rat
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
Storage
Protocol
Specificity / Sensitivity
Neurogenin 2 (D2R3D) Rabbit mAb recognizes endogenous levels of total neurogenin 2 protein.
Species Reactivity:
Human, Mouse, Rat
Source / Purification
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human neurogenin 2 protein.
Background
Neurogenin 2 (Ngn2, NeuroG2) is a proneural, basic helix-loop-helix transcription (bHLH) factor and member of the neurogenin family that includes neurogenin 1 and neurogenin 3 (1). Neurogenin 2 is expressed in neuronal progenitor cells, is required for generation of glutamatergic neurons and is commonly used as a marker of neuronal differentiation (2,3). Neurogenin 2 upregulates a number of targets including the bHLH transcription factor NeuroD (4). Phosphorylation of Ngn2 at Tyr241 controls migration and dendritic morphology of cortical neurons (5).
Limited Uses
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