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  2. Primary Antibodies /
  3. Neuronatin Antibody

Neuronatin Antibody #78122

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  • WB
  • IP

    Supporting Data

    REACTIVITY H M R
    SENSITIVITY Endogenous
    MW (kDa) 9,10
    SOURCE Rabbit
    Application Key:
    • WB-Western Blotting 
    • IP-Immunoprecipitation 
    Species Cross-Reactivity Key:
    • H-Human 
    • M-Mouse 
    • R-Rat 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000
    Immunoprecipitation 1:50

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, and 50% glycerol. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    Neuronatin Antibody recognizes endogenous levels of total neuronatin protein.

    Species Reactivity:

    Human, Mouse, Rat

    Source / Purification

    Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Gly73 of mouse neuronatin protein. Antibodies are purified by protein A and peptide affinity chromatography.

    Background

    Neuronatin (NNAT) is a cytoplasmic protein that may be important for brain development due to its high expression in early developing brain (1). Multiple neuronatin isoforms are generated by alternative splicing, including NNATα and NNATβ. Although neuronatin plays a role in establishing the central and peripheral nervous system in the final stages of embryogenesis, neuronatin expression is maintained in other tissues after development, including the hypothalamus, pancreatic β-cells, and adipocytes, suggesting additional neuronatin functions, particularly in metabolism (2,3). While neuronatin’s cellular function remains incompletely understood, neuronatin is homologous to proteins, such as phospholamban and sarcolipin, that regulate sarcoplasmic and endoplasmic reticulum Ca2+ ATPases (SERCA) pumps (3). By regulating cellular Ca2+ homeostasis, neuronatin may play a critical role in brain development as well as metabolic regulation. 

    Database Links

    UniProt ID: Q61979


    Entrez-Gene Id: 18111


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    For Research Use Only. Not For Use In Diagnostic Procedures.
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