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XML generation date: 2024-04-05 20:19:37.158
Product last modified at: 2024-10-18T21:00:14.151Z
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PDP - Template Name: Antibody Sampler Kit
PDP - Template ID: *******4a3ef3a

OAS/RNase L Pathway Antibody Sampler Kit #60125

    Product Information

    Product Description

    The OAS/RNase L Pathway Antibody Sampler Kit provides an economical means of detecting proteins involved in the OAS/RNase L pathway. The kit includes enough antibodies to perform two western blot experiments with each primary antibody.

    Background

    The 2'-5'-oligoadenylate synthetase (OAS)/RNase L pathway is a component of the antiviral innate immune system. The OAS family of proteins includes OAS1, OAS2, OAS3, and OASL in humans, all of which are induced in response to type 1 interferons (1-3). When activated by cytosolic double-stranded RNA, OAS1-3 generate 2’-5’-linked oligoadenylates that bind to and activate the ribonuclease, RNase L. Activated RNase L is poised to degrade viral and cellular RNA as part of the antiviral innate immune response (4). Unlike OAS1-3, OASL lacks intrinsic enzymatic activity, and research studies have suggested that OASL participates in the antiviral immune response independently of the canonical OAS/RNase L signaling pathway (5,6). Negative regulation of the OAS/RNase L pathway is governed, in part, by the PDE12 phosphodiesterase that degrades 2'-5'-oligoadenylates (7).
    For Research Use Only. Not For Use In Diagnostic Procedures.
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