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OGF Receptor (F7I9M) Rabbit Monoclonal Antibody #32151

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  • WB

    Product Specifications

    REACTIVITY H
    SENSITIVITY Endogenous
    MW (kDa) 100-110
    Source/Isotype Rabbit IgG
    Application Key:
    • WB-Western Blotting 
    Species Cross-Reactivity Key:
    • H-Human 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    OGF Receptor (F7I9M) Rabbit Monoclonal Antibody recognizes endogenous levels of total OGF Receptor protein. This antibody is predicted to detect isoforms 1 and 2 of OGF Receptor protein.

    Species Reactivity:

    Human

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Glu100 of human OGF Receptor protein.

    Background

    Opioid growth factor receptor (OGFr) is the high-affinity receptor for the opioid growth factor (OGF), also known as [Met5]-enkephalin (1,2). The OGF-OGFr axis acts as an inhibitory system for regulating cell replication and homeostasis (1,2). This complex induces the synthesis of cyclin-dependent kinase (CDK) inhibitors p16 and p21, which causes the cell cycle to pause in the G1 phase, preventing further cell division (3,4). When bound to OGF, OGFr translocates from the outer nuclear envelope into the nucleus (5). Blocking of the OGF-OGFr interaction using the opioid agonist naltrexone (NTX) increases the rate of cell growth and stimulates restoration of homeostasis and wound repair (5).

    Alternate Names

    7-60 protein; OGFR; Opioid growth factor receptor; Protein 7-60; Zeta-type opioid receptor

    For Research Use Only. Not for Use in Diagnostic Procedures.
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