Cat. # | Size | Qty. | Price |
---|---|---|---|
38289T | 1 Kit (8 x 20 microliters) |
|
Product Includes | Quantity | Applications | Reactivity | MW(kDa) | Isotype |
---|---|---|---|---|---|
Olig2 (E6G6Q) XP® Rabbit mAb 65915 | 20 µl |
|
H M R | 35 | Rabbit IgG |
Myelin Basic Protein (D8X4Q) XP® Rabbit mAb 78896 | 20 µl |
|
H M R | 12-18 | Rabbit IgG |
CNPase (D83E10) XP® Rabbit mAb 5664 | 20 µl |
|
H M R | 47 | Rabbit IgG |
PLP1 (E9V1N) Rabbit mAb 28702 | 20 µl |
|
H M R | 20-30 | Rabbit IgG |
MAG (D4G3) XP® Rabbit mAb 9043 | 20 µl |
|
H M R | 100 | Rabbit IgG |
MOG (E5K6T) XP® Rabbit mAb 96457 | 20 µl |
|
H M R | 46, 35, 28, 23 | Rabbit IgG |
NG2/CSPG4 (E3B3G) XP® Rabbit mAb 43916 | 20 µl |
|
H | 250, 450 | Rabbit IgG |
Sox10 (E6B6I) XP® Rabbit mAb 69661 | 20 µl |
|
H | 62 | Rabbit IgG |
Anti-rabbit IgG, HRP-linked Antibody 7074 | 100 µl |
|
Goat |
Product Information
Monoclonal antibodies are produced by immunizing animals with synthetic peptides corresponding to residues surrounding Ala185 of human myelin basic protein, Val81 of human CNPase protein, Arg605 of human MAG protein, Asp1410 of human NG2/CSPG4 protein, Gly446 of human Sox10 protein, recombinant protein specific to the carboxy terminus of human Olig2 protein and human PLP1 protein, and recombinant protein specific to the extracellular membrane proximal amino terminus of human MOG protein.
Oligodendrocytes are the myelinating glial cells of the central nervous system (CNS) (1). Myelin basic protein (MBP) is an abundant CNS myelin membrane protein that plays an important role in nerve myelination. MBP helps to adhere the cytoplasmic leaflets of adjacent oligodendrocyte membranes to one another (2). CNPase (2', 3'-cyclic nucleotide 3'-phosphodiesterase) is an enzyme highly expressed in oligodendrocytes and accounts for roughly 4% of the total myelin protein in the CNS (3). CNPase binds to tubulin heterodimers and plays a role in tubulin polymerization, and oligodendrocyte process outgrowth (4). Myelin proteolipid protein (PLP1) corresponds to the majority of myelin proteins in the CNS, providing support to axons and modulating axonal growth (5). Myelin-associated glycoprotein (MAG) is localized in oligodendroglial membranes of myelin sheaths where it plays a role in interaction between axons and glia, and has been shown to promote axonal protective effects (6,7). Chondroitin sulfate proteoglycan 4 (CSP4, NG2) is a type I membrane glycoprotein expressed by oligodendroglial precursor cells (OPCs) that plays a role in cell attachment and migration (8). SRY-box 10 (Sox10) is a high-mobility group transcription factor expressed throughout oligodendrocyte development required for myelin gene expression (9,10). Myelin-oligodendrocyte glycoprotein (MOG) is a type I membrane bound glycoprotein of the immunoglobulin superfamily that is enriched in the outer lamella of the myelin sheath (11). Olig2 is a basic helix–loop–helix (bHLH) transcription factor necessary for oligodendrocyte and motor neuron differentiation and development in the CNS (12,13). Olig2 has been shown to be a useful marker for primary and mature oligodendrocytes and is universally expressed in diffuse gliomas (14,15).
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