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OMP25/SYNJ2BP (F5X5O) Rabbit Monoclonal Antibody #62577

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  • WB
  • IP

    Product Specifications

    REACTIVITY H M
    SENSITIVITY Endogenous
    MW (kDa) 16
    Source/Isotype Rabbit IgG
    Application Key:
    • WB-Western Blotting 
    • IP-Immunoprecipitation 
    Species Cross-Reactivity Key:
    • H-Human 
    • M-Mouse 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000
    Immunoprecipitation 1:200

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    OMP25/SYNJ2BP (F5X5O) Rabbit Monoclonal Antibody recognizes endogenous levels of total OMP25/SYNJ2BP protein.

    Species Reactivity:

    Human, Mouse

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with a recombinant protein specific to the amino terminus of human OMP25/SYNJ2BP protein.

    Background

    Synaptojanin-2 binding protein (SYNJ2BP), also known as OMP25, is a mitochondrial outer membrane protein that acts as a signaling hub, regulating crucial processes in the brain, including neuron function and inter-organelle communication. A key function of SYNJ2BP is managing the contact between mitochondria and the endoplasmic reticulum (ER), known as mitochondrial-ER contact sites (MERCs) (1). Specifically in neurons, SYNJ2BP and Synaptojanin-2 (SYNJ2) form a tethering complex that latches PTEN induced putative kinase 1 (PINK1) mRNA onto the mitochondria. This specialized mechanism enables the local translation of PINK1 in distal parts of the cell, ensuring that distant mitochondria receive a steady supply of the protein required to activate mitophagy (2). By regulating the contact points between the ER and mitochondria in the liver, SYNJ2BP also plays a role in regulating hepatic lipid flux (3).

    Alternate Names

    activin receptor interacting protein 5; ARIP2; FLJ11271; FLJ41973; Mitochondrial outer membrane protein 25; OMP25; SYJ2B; synaptojanin 2 binding protein; Synaptojanin-2-binding protein; SYNJ2BP

    For Research Use Only. Not for Use in Diagnostic Procedures.
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