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6923
PANK2 Antibody (Mouse Specific)
Primary Antibodies

PANK2 Antibody (Mouse Specific) #6923

This product is discontinued

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# Product Name Application Reactivity
  • WB
  • IP
M
Storage:

Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.

PANK2 Antibody (Mouse Specific) recognizes endogenous levels of total PANK2 protein.

Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues near the amino terminus of mouse PANK2 protein. Antibodies are purified by protein A and peptide affinity chromatography.

PANK2, pantothenate kinase 2, catalyzes the first step in CoA biosynthesis (1,2). Human PANK2 is located in the mitochondria, and research studies have shown some mutations in human PANK2 are linked to neurodegeneration (2). Alternatively, mouse PANK2 localizes in the cytosol, and defective PANK2 in mice leads to retinal degeneration (1,3).

  1. Leonardi, R. et al. (2007) FEBS Lett 581, 4639-44.
  2. Zhang, Y.M. et al. (2006) J Biol Chem 281, 107-14.
  3. Kuo, Y.M. et al. (2005) Hum Mol Genet 14, 49-57.
Entrez-Gene Id
74450
Swiss-Prot Acc.
Q7M753
For Research Use Only. Not For Use In Diagnostic Procedures.

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