| Cat. # | Size | Qty. | Price |
|---|---|---|---|
| 74113T | 1 Kit (9 x 20 microliters) |
|
$ 708 |
| Product Includes | Quantity | Applications | Reactivity | MW(kDa) | Isotype |
|---|---|---|---|---|---|
| β-Amyloid (D54D2) XP® Rabbit mAb 8243 | 20 µl |
|
H | 5 | Rabbit IgG |
| β-Amyloid (1-42) (D9A3A) Rabbit mAb 14974 | 20 µl |
|
H | 4 | Rabbit IgG |
| β-Amyloid (1-40) (D8Q7I) Rabbit mAb 12990 | 20 µl |
|
H | 4 | Rabbit IgG |
| β-Amyloid (1-43) (E8C2D) Rabbit mAb 32098 | 20 µl |
|
H | 6 | Rabbit IgG |
| β-Amyloid (pE3 Peptide) (D5N5H) Rabbit mAb 14975 | 20 µl |
|
H | 4 | Rabbit IgG |
| Tau (D1M9X) XP® Rabbit mAb 46687 | 20 µl |
|
H M R | 50-80 | Rabbit IgG |
| Phospho-Tau (Thr205) (E7D3E) Rabbit mAb 49561 | 20 µl |
|
H M R | 50-80 | Rabbit IgG |
| Phospho-Tau (Ser404) (D2Z4G) Rabbit mAb 20194 | 20 µl |
|
H M R | 50-80 | Rabbit IgG |
| Phospho-Tau (Thr181) (D9F4G) Rabbit mAb 12885 | 20 µl |
|
H M R | 50-80 | Rabbit IgG |
| Anti-rabbit IgG, HRP-linked Antibody 7074 | 100 µl |
|
Rab | Goat |
Product Information
Tau antibodies include peptides corresponding to residues surrounding Asp430, phosphorylated at Thr205, Ser400/Thr403/Ser404, and Thr181 of human tau. Monoclonal antibodies are produced by immunizing rabbits with synthetic Aβ peptides corresponding to residues near the carboxy terminus of human β-amyloid (1-42), (1-40), (1-43), (pE3) peptide, and several peptides of Aβ, such as Aβ-37, Aβ-38, Aβ-39, Aβ-40, and Aβ-42.
Tau is a heterogeneous microtubule-associated protein that promotes and stabilizes microtubule assembly, especially in axons. Six isoforms with different amino-terminal inserts and different numbers of tandem repeats near the carboxy terminus have been identified, and tau is hyperphosphorylated at approximately 25 sites by ERK, GSK-3, and CDK5 (1,2). Phosphorylation decreases the ability of tau to bind to microtubules. Neurofibrillary tangles are a major hallmark of Alzheimer's disease; these tangles are bundles of paired helical filaments composed of hyperphosphorylated tau. In particular, phosphorylation at Ser396 by GSK-3 or CDK5 destabilizes microtubules. Furthermore, research studies have shown that inclusions of tau are found in a number of other neurodegenerative diseases, collectively known as tauopathies (1,3). The cerebrospinal fluid concentration of tau phosphorylated at Thr181 has been proposed to be a biomarker for the study of neurodegenerative disorders (4).
Amyloid β (Aβ) precursor protein (APP) is a 100-140 kDa transmembrane glycoprotein that exists as several isoforms (4). The amino acid sequence of APP contains the amyloid domain, which can be released by a two-step proteolytic cleavage (4). The extracellular deposition and accumulation of the released Aβ fragments form the main components of amyloid plaques in Alzheimer's disease (4). APP can be phosphorylated at several sites, which may affect the proteolytic processing and secretion of this protein (5-8). Aβ-43 has been suggested as a biomarker in early onset of Alzheimer's disease, where patients have lower levels of Aβ-43 in cerebrospinal fluid (8-10). Several studies have shown that Aβ toxicity of Aβ-43 is as high as Aβ-42 or Aβ-40 in different models of Alzheimer's disease, including mouse models and human disease (10).
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STRING - Known and Predicted Protein-Protein Interactions.
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