Render Target: STATIC
Render Timestamp:
5/20/2026, 6:06:15 AM EDT
5/20/2026, 10:06:15 AM UTC
Commit: 7ed46ecc04b401f23a28df741b5078df405d23e4
XML generation date: 2025-11-19 22:14:03.504
Product last modified at: 2026-03-20T08:10:09.781Z
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PDP - Template Name: Antibody Duet
PDP - Template ID: *******ad0fa02

PhosphoPlus® PFKFB2 (Ser483) Antibody Duet #39527

    Product Information

    Product Description

    PhosphoPlus® Duets from Cell Signaling Technology (CST) provide a means to assess protein activation status. Each Duet contains an activation-state and total protein antibody to your target of interest. These antibodies have been selected from CST's product offering based upon superior performance in specified applications.

    Background

    The bifunctional 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFK/FBPase or PFKFB) catalyzes the synthesis and degradation of fructose 2,6-bisphosphate and regulates its steady-state level (1,2). Fructose 2,6-bisphosphate activates phosphofructokinase, a rate-limiting enzyme in glycolysis, by allosteric regulation (1,2). Four different PFKFB isoforms (PFKFB1, PFKFB2, PFKFB3, and PFKFB4) have been identified (1,2). Research studies indicate that amino acids activate PFKFB2 through Akt-dependent phosphorylation at Ser483 on PFKFB2 (3). In addition, androgen increases the expression of PFKFB2 in prostate cancer cells (4).

    Alternate Names

    6-phosphofructo-2-kinase; 6-phosphofructo-2-kinase/fructose-26-biphosphatase 2; 6-phosphofructo-2-kinase/fructose-26-bisphosphatase 2; 6PF-2-K/Fru-26-P2ase 2; 6PF-2-K/Fru-26-P2ase heart-type isozyme; Fructose-26-bisphosphatase; fructose-26-bisphosphatase cardiac isozyme; PFK-2/FBPase-2; PFK/FBPase 2; PFKFB cardiac; PFKFB2

    For Research Use Only. Not for Use in Diagnostic Procedures.
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