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  1. Products /
  2. Primary Antibodies /
  3. PGD Antibody

PGD Antibody #13389

Filter:
  • WB

    Supporting Data

    REACTIVITY H
    SENSITIVITY Endogenous
    MW (kDa) 49
    SOURCE Rabbit
    Application Key:
    • WB-Western Blotting 
    Species Cross-Reactivity Key:
    • H-Human 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    PGD Antibody recognizes endogenous levels of total PGD protein.

    Species Reactivity:

    Human

    Source / Purification

    Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ala300 of human PGD protein. Antibodies are purified by protein A and peptide affinity chromatography.

    Background

    6-phosphogluconate dehydrogenase (PGD or 6PGD) catalyzes the conversion of 6-phosphogluconate and NADP+ to ribulose 5-phosphate and NADPH in the pentose phosphate pathway (1). Research studies show that knockdown of PGD results in the induction of senescence and inhibition of growth of lung cancer cells (2). Additional research suggests that PGD influences the migration of some cancer cells by regulating c-Met phosphorylation state (3). Furthermore, it was shown that the glycolytic enzyme PGAM1 substrate (3-phosphoglycerate) regulates the pentose phosphate pathway by deactivating PGD/6PGD (4).

    Database Links

    UniProt ID: P52209


    Entrez-Gene Id: 5226


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    For Research Use Only. Not For Use In Diagnostic Procedures.
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