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11834
Phospho-Tau (Ser202) Antibody

Phospho-Tau (Ser202) Antibody #11834

This product is discontinued

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Storage:

Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.

Phospho-Tau (Ser202) Antibody recognizes endogenous levels of Tau protein only when phosphorylated at Ser202.

Polyclonal antibodies are produced by immunizing animals with a synthetic phosphopeptide corresponding to residues surrounding Ser202 of human Tau protein. Antibodies are purified by protein A and peptide affinity chromatography.

Tau is a heterogeneous microtubule-associated protein that promotes and stabilizes microtubule assembly, especially in axons. Six isoforms with different amino-terminal inserts and different numbers of tandem repeats near the carboxy terminus have been identified, and tau is hyperphosphorylated at approximately 25 sites by Erk, GSK-3, and CDK5 (1,2). Phosphorylation decreases the ability of tau to bind to microtubules. Neurofibrillary tangles are a major hallmark of Alzheimer's disease; these tangles are bundles of paired helical filaments composed of hyperphosphorylated tau. In particular, phosphorylation at Ser396 by GSK-3 or CDK5 destabilizes microtubules. Furthermore, research studies have shown that inclusions of tau are found in a number of other neurodegenerative diseases, collectively known as tauopathies (1,3).

Investigators have shown that Tau is phosphorylated during development and hyper-phosphorylated at Ser202 in Alzheimer's disease (4).

  1. Johnson, G.V. and Stoothoff, W.H. (2004) J Cell Sci 117, 5721-9.
  2. Hanger, D.P. et al. (1998) J Neurochem 71, 2465-76.
  3. Bramblett, G.T. et al. (1993) Neuron 10, 1089-99.
  4. Goedert, M. et al. (1993) Proc Natl Acad Sci U S A 90, 5066-70.
Entrez-Gene Id
4137
Swiss-Prot Acc.
P10636-8
For Research Use Only. Not For Use In Diagnostic Procedures.

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