Phospho-Tau (Ser46) Antibody #20296
- WB
Supporting Data
| REACTIVITY | H M R |
| SENSITIVITY | Endogenous |
| MW (kDa) | 50-80 |
| SOURCE | Rabbit |
Application Key:
- WB-Western Blotting
Species Cross-Reactivity Key:
- H-Human
- M-Mouse
- R-Rat
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
Storage
Protocol
Specificity / Sensitivity
Species Reactivity:
Source / Purification
Background
Phosphorylation of Tau at Ser46 is induced by different kinases, including GSK-3β (4), casein kinase-1 (5), and p38MAPK (6). Tau phosphorylation at Ser46 has been linked to different neurodegenerative diseases, including in PHF-Tau from Alzheimer's disease (4,6), Progressive Supranuclear Palsy (7), and synucleinopathies (6).
- Johnson, G.V. and Stoothoff, W.H. (2004) J Cell Sci 117, 5721-9.
- Hanger, D.P. et al. (1998) J Neurochem 71, 2465-76.
- Bramblett, G.T. et al. (1993) Neuron 10, 1089-99.
- Godemann, R. et al. (1999) FEBS Lett 454, 157-64.
- Hanger, D.P. et al. (2007) J Biol Chem 282, 23645-54.
- Duka, V. et al. (2013) PLoS One 8, e75025.
- Wray, S. et al. (2008) J Neurochem 105, 2343-52.
Limited Uses
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